Performance characteristics of a rapid SARS-CoV-2 antigen detection assay at a public plaza testing site in San Francisco.
Identifieur interne : 000051 ( Main/Exploration ); précédent : 000050; suivant : 000052Performance characteristics of a rapid SARS-CoV-2 antigen detection assay at a public plaza testing site in San Francisco.
Auteurs : Genay Pilarowski [États-Unis] ; Paul Lebel [États-Unis] ; Sara Sunshine [États-Unis] ; Jamin Liu [États-Unis] ; Emily Crawford [États-Unis] ; Carina Marquez [États-Unis] ; Luis Rubio [États-Unis] ; Gabriel Chamie [États-Unis] ; Jackie Martinez [États-Unis] ; James Peng [États-Unis] ; Douglas Black [États-Unis] ; Wesley Wu [États-Unis] ; John Pak [États-Unis] ; Matthew T. Laurie [États-Unis] ; Diane Jones [États-Unis] ; Steve Miller [États-Unis] ; Jon Jacobo [États-Unis] ; Susana Rojas [États-Unis] ; Susy Rojas [États-Unis] ; Robert Nakamura [États-Unis] ; Valerie Tulier-Laiwa [États-Unis] ; Maya Petersen [États-Unis] ; Diane V. Havlir [États-Unis] ; Joseph Derisi [États-Unis]Source :
- The Journal of infectious diseases [ 1537-6613 ] ; 2021.
Abstract
We evaluated the performance of the Abbott BinaxNOW TM Covid-19 rapid antigen test (Binax-CoV2) to detect virus among persons, regardless of symptoms, at a public plaza site of ongoing community transmission. Titration with cultured SARS-CoV-2 yielded a human observable threshold between 1.6x10 4-4.3x10 4 viral RNA copies (cycle threshold (Ct) of 30.3-28.8). Among 878 subjects tested, 3% (26/878) were positive by RT-PCR, of which 15/26 had Ct<30, indicating high viral load. 40% (6/15) of Ct<30 were asymptomatic. Using this Ct<30 threshold for Binax-CoV2 evaluation, the sensitivity of Binax-CoV2 was 93.3% (14/15), 95% CI: 68.1-99.8%, and the specificity was 99.9% (855/856), 95% CI: 99.4-99.9%.
DOI: 10.1093/infdis/jiaa802
PubMed: 33394052
PubMed Central: PMC7799021
Affiliations:
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Medicine, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chamie, Gabriel" sort="Chamie, Gabriel" uniqKey="Chamie G" first="Gabriel" last="Chamie">Gabriel Chamie</name><affiliation wicri:level="2"><nlm:affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Martinez, Jackie" sort="Martinez, Jackie" uniqKey="Martinez J" first="Jackie" last="Martinez">Jackie Martinez</name><affiliation wicri:level="2"><nlm:affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Peng, James" sort="Peng, James" uniqKey="Peng J" first="James" last="Peng">James Peng</name><affiliation wicri:level="2"><nlm:affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Black, Douglas" sort="Black, Douglas" uniqKey="Black D" first="Douglas" last="Black">Douglas Black</name><affiliation wicri:level="2"><nlm:affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wu, Wesley" sort="Wu, Wesley" uniqKey="Wu W" first="Wesley" last="Wu">Wesley Wu</name><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Pak, John" sort="Pak, John" uniqKey="Pak J" first="John" last="Pak">John Pak</name><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Laurie, Matthew T" sort="Laurie, Matthew T" uniqKey="Laurie M" first="Matthew T" last="Laurie">Matthew T. Laurie</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Biophysics, University of California San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Biophysics, University of California San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jones, Diane" sort="Jones, Diane" uniqKey="Jones D" first="Diane" last="Jones">Diane Jones</name><affiliation wicri:level="2"><nlm:affiliation>Unidos en Salud, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Unidos en Salud, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Miller, Steve" sort="Miller, Steve" uniqKey="Miller S" first="Steve" last="Miller">Steve Miller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, University of California San Francisco CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine, University of California San Francisco CA</wicri:regionArea><wicri:noRegion>University of California San Francisco CA</wicri:noRegion></affiliation></author><author><name sortKey="Jacobo, Jon" sort="Jacobo, Jon" uniqKey="Jacobo J" first="Jon" last="Jacobo">Jon Jacobo</name><affiliation wicri:level="2"><nlm:affiliation>Latino Task Force-COVID-19, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Latino Task Force-COVID-19, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rojas, Susana" sort="Rojas, Susana" uniqKey="Rojas S" first="Susana" last="Rojas">Susana Rojas</name><affiliation wicri:level="2"><nlm:affiliation>Latino Task Force-COVID-19, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Latino Task Force-COVID-19, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rojas, Susy" sort="Rojas, Susy" uniqKey="Rojas S" first="Susy" last="Rojas">Susy Rojas</name><affiliation wicri:level="2"><nlm:affiliation>Latino Task Force-COVID-19, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Latino Task Force-COVID-19, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nakamura, Robert" sort="Nakamura, Robert" uniqKey="Nakamura R" first="Robert" last="Nakamura">Robert Nakamura</name><affiliation wicri:level="2"><nlm:affiliation>California Department of Public Health, Microbial Diseases Laboratory, Richmond, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>California Department of Public Health, Microbial Diseases Laboratory, Richmond, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tulier Laiwa, Valerie" sort="Tulier Laiwa, Valerie" uniqKey="Tulier Laiwa V" first="Valerie" last="Tulier-Laiwa">Valerie Tulier-Laiwa</name><affiliation wicri:level="2"><nlm:affiliation>Latino Task Force-COVID-19, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Latino Task Force-COVID-19, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Petersen, Maya" sort="Petersen, Maya" uniqKey="Petersen M" first="Maya" last="Petersen">Maya Petersen</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology and Biostatistics, University of California, Berkeley, Berkeley, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Biostatistics, University of California, Berkeley, Berkeley, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Havlir, Diane V" sort="Havlir, Diane V" uniqKey="Havlir D" first="Diane V" last="Havlir">Diane V. 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xml:lang="en">Performance characteristics of a rapid SARS-CoV-2 antigen detection assay at a public plaza testing site in San Francisco.</title><author><name sortKey="Pilarowski, Genay" sort="Pilarowski, Genay" uniqKey="Pilarowski G" first="Genay" last="Pilarowski">Genay Pilarowski</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Stanford (Californie)</settlement></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Lebel, Paul" sort="Lebel, Paul" uniqKey="Lebel P" first="Paul" last="Lebel">Paul Lebel</name><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sunshine, Sara" sort="Sunshine, Sara" uniqKey="Sunshine S" first="Sara" last="Sunshine">Sara Sunshine</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Biophysics, University of California San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Biophysics, University of California San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Liu, Jamin" sort="Liu, Jamin" uniqKey="Liu J" first="Jamin" last="Liu">Jamin Liu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Biophysics, University of California San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Biophysics, University of California San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Crawford, Emily" sort="Crawford, Emily" uniqKey="Crawford E" first="Emily" last="Crawford">Emily Crawford</name><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of California San Francisco, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, University of California San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Marquez, Carina" sort="Marquez, Carina" uniqKey="Marquez C" first="Carina" last="Marquez">Carina Marquez</name><affiliation wicri:level="2"><nlm:affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rubio, Luis" sort="Rubio, Luis" uniqKey="Rubio L" first="Luis" last="Rubio">Luis Rubio</name><affiliation wicri:level="2"><nlm:affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chamie, Gabriel" sort="Chamie, Gabriel" uniqKey="Chamie G" first="Gabriel" last="Chamie">Gabriel Chamie</name><affiliation wicri:level="2"><nlm:affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Martinez, Jackie" sort="Martinez, Jackie" uniqKey="Martinez J" first="Jackie" last="Martinez">Jackie Martinez</name><affiliation wicri:level="2"><nlm:affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Peng, James" sort="Peng, James" uniqKey="Peng J" first="James" last="Peng">James Peng</name><affiliation wicri:level="2"><nlm:affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Black, Douglas" sort="Black, Douglas" uniqKey="Black D" first="Douglas" last="Black">Douglas Black</name><affiliation wicri:level="2"><nlm:affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wu, Wesley" sort="Wu, Wesley" uniqKey="Wu W" first="Wesley" last="Wu">Wesley Wu</name><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Pak, John" sort="Pak, John" uniqKey="Pak J" first="John" last="Pak">John Pak</name><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Laurie, Matthew T" sort="Laurie, Matthew T" uniqKey="Laurie M" first="Matthew T" last="Laurie">Matthew T. Laurie</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Biophysics, University of California San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Biophysics, University of California San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jones, Diane" sort="Jones, Diane" uniqKey="Jones D" first="Diane" last="Jones">Diane Jones</name><affiliation wicri:level="2"><nlm:affiliation>Unidos en Salud, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Unidos en Salud, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Miller, Steve" sort="Miller, Steve" uniqKey="Miller S" first="Steve" last="Miller">Steve Miller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, University of California San Francisco CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine, University of California San Francisco CA</wicri:regionArea><wicri:noRegion>University of California San Francisco CA</wicri:noRegion></affiliation></author><author><name sortKey="Jacobo, Jon" sort="Jacobo, Jon" uniqKey="Jacobo J" first="Jon" last="Jacobo">Jon Jacobo</name><affiliation wicri:level="2"><nlm:affiliation>Latino Task Force-COVID-19, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Latino Task Force-COVID-19, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rojas, Susana" sort="Rojas, Susana" uniqKey="Rojas S" first="Susana" last="Rojas">Susana Rojas</name><affiliation wicri:level="2"><nlm:affiliation>Latino Task Force-COVID-19, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Latino Task Force-COVID-19, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rojas, Susy" sort="Rojas, Susy" uniqKey="Rojas S" first="Susy" last="Rojas">Susy Rojas</name><affiliation wicri:level="2"><nlm:affiliation>Latino Task Force-COVID-19, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Latino Task Force-COVID-19, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nakamura, Robert" sort="Nakamura, Robert" uniqKey="Nakamura R" first="Robert" last="Nakamura">Robert Nakamura</name><affiliation wicri:level="2"><nlm:affiliation>California Department of Public Health, Microbial Diseases Laboratory, Richmond, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>California Department of Public Health, Microbial Diseases Laboratory, Richmond, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tulier Laiwa, Valerie" sort="Tulier Laiwa, Valerie" uniqKey="Tulier Laiwa V" first="Valerie" last="Tulier-Laiwa">Valerie Tulier-Laiwa</name><affiliation wicri:level="2"><nlm:affiliation>Latino Task Force-COVID-19, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Latino Task Force-COVID-19, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Petersen, Maya" sort="Petersen, Maya" uniqKey="Petersen M" first="Maya" last="Petersen">Maya Petersen</name><affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology and Biostatistics, University of California, Berkeley, Berkeley, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Biostatistics, University of California, Berkeley, Berkeley, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Havlir, Diane V" sort="Havlir, Diane V" uniqKey="Havlir D" first="Diane V" last="Havlir">Diane V. Havlir</name><affiliation wicri:level="2"><nlm:affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Derisi, Joseph" sort="Derisi, Joseph" uniqKey="Derisi J" first="Joseph" last="Derisi">Joseph Derisi</name><affiliation wicri:level="2"><nlm:affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chan Zuckerberg Biohub, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Biophysics, University of California San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Biophysics, University of California San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We evaluated the performance of the Abbott BinaxNOW TM Covid-19 rapid antigen test (Binax-CoV2) to detect virus among persons, regardless of symptoms, at a public plaza site of ongoing community transmission. Titration with cultured SARS-CoV-2 yielded a human observable threshold between 1.6x10 4-4.3x10 4 viral RNA copies (cycle threshold (Ct) of 30.3-28.8). Among 878 subjects tested, 3% (26/878) were positive by RT-PCR, of which 15/26 had Ct<30, indicating high viral load. 40% (6/15) of Ct<30 were asymptomatic. Using this Ct<30 threshold for Binax-CoV2 evaluation, the sensitivity of Binax-CoV2 was 93.3% (14/15), 95% CI: 68.1-99.8%, and the specificity was 99.9% (855/856), 95% CI: 99.4-99.9%.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33394052</PMID><DateRevised><Year>2021</Year><Month>01</Month><Day>26</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2021</Year><Month>Jan</Month><Day>04</Day></PubDate></JournalIssue><Title>The Journal of infectious diseases</Title><ISOAbbreviation>J Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Performance characteristics of a rapid SARS-CoV-2 antigen detection assay at a public plaza testing site in San Francisco.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">jiaa802</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiaa802</ELocationID><Abstract><AbstractText>We evaluated the performance of the Abbott BinaxNOW TM Covid-19 rapid antigen test (Binax-CoV2) to detect virus among persons, regardless of symptoms, at a public plaza site of ongoing community transmission. Titration with cultured SARS-CoV-2 yielded a human observable threshold between 1.6x10 4-4.3x10 4 viral RNA copies (cycle threshold (Ct) of 30.3-28.8). Among 878 subjects tested, 3% (26/878) were positive by RT-PCR, of which 15/26 had Ct<30, indicating high viral load. 40% (6/15) of Ct<30 were asymptomatic. Using this Ct<30 threshold for Binax-CoV2 evaluation, the sensitivity of Binax-CoV2 was 93.3% (14/15), 95% CI: 68.1-99.8%, and the specificity was 99.9% (855/856), 95% CI: 99.4-99.9%.</AbstractText><CopyrightInformation>© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pilarowski</LastName><ForeName>Genay</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lebel</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sunshine</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Biophysics, University of California San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jamin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Biophysics, University of California San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crawford</LastName><ForeName>Emily</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of California San Francisco, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marquez</LastName><ForeName>Carina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rubio</LastName><ForeName>Luis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chamie</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martinez</LastName><ForeName>Jackie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Black</LastName><ForeName>Douglas</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Wesley</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pak</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laurie</LastName><ForeName>Matthew T</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Biophysics, University of California San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Diane</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Unidos en Salud, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miller</LastName><ForeName>Steve</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine, University of California San Francisco CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacobo</LastName><ForeName>Jon</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Latino Task Force-COVID-19, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rojas</LastName><ForeName>Susana</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Latino Task Force-COVID-19, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rojas</LastName><ForeName>Susy</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Latino Task Force-COVID-19, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nakamura</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>California Department of Public Health, Microbial Diseases Laboratory, Richmond, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tulier-Laiwa</LastName><ForeName>Valerie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Latino Task Force-COVID-19, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petersen</LastName><ForeName>Maya</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Epidemiology and Biostatistics, University of California, Berkeley, Berkeley, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Havlir</LastName><ForeName>Diane V</ForeName><Initials>DV</Initials><AffiliationInfo><Affiliation>Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>CLIAHUB Consortium</CollectiveName></Author><Author ValidYN="Y"><LastName>DeRisi</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Chan Zuckerberg Biohub, San Francisco, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry and Biophysics, University of California San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>01</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Infect Dis</MedlineTA><NlmUniqueID>0413675</NlmUniqueID><ISSNLinking>0022-1899</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="UpdateOf"><RefSource>medRxiv. 2020 Nov 04;:</RefSource><PMID Version="1">33173911</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Point of Care testing</Keyword><Keyword MajorTopicYN="N">Rapid Antigen Test</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>11</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>1</Month><Day>4</Day><Hour>12</Hour><Minute>13</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>1</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>1</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33394052</ArticleId><ArticleId IdType="pii">6061974</ArticleId><ArticleId IdType="doi">10.1093/infdis/jiaa802</ArticleId><ArticleId IdType="pmc">PMC7799021</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Stanford (Californie)</li></settlement><orgName><li>Université Stanford</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Pilarowski, Genay" sort="Pilarowski, Genay" uniqKey="Pilarowski G" first="Genay" last="Pilarowski">Genay Pilarowski</name></region><name sortKey="Black, Douglas" sort="Black, Douglas" uniqKey="Black D" first="Douglas" last="Black">Douglas Black</name><name sortKey="Chamie, Gabriel" sort="Chamie, Gabriel" uniqKey="Chamie G" first="Gabriel" last="Chamie">Gabriel Chamie</name><name sortKey="Crawford, Emily" sort="Crawford, Emily" uniqKey="Crawford E" first="Emily" last="Crawford">Emily Crawford</name><name sortKey="Crawford, Emily" sort="Crawford, Emily" uniqKey="Crawford E" first="Emily" last="Crawford">Emily Crawford</name><name sortKey="Derisi, Joseph" sort="Derisi, Joseph" uniqKey="Derisi J" first="Joseph" last="Derisi">Joseph Derisi</name><name sortKey="Derisi, Joseph" sort="Derisi, Joseph" uniqKey="Derisi J" first="Joseph" last="Derisi">Joseph Derisi</name><name sortKey="Havlir, Diane V" sort="Havlir, Diane V" uniqKey="Havlir D" first="Diane V" last="Havlir">Diane V. Havlir</name><name sortKey="Jacobo, Jon" sort="Jacobo, Jon" uniqKey="Jacobo J" first="Jon" last="Jacobo">Jon Jacobo</name><name sortKey="Jones, Diane" sort="Jones, Diane" uniqKey="Jones D" first="Diane" last="Jones">Diane Jones</name><name sortKey="Laurie, Matthew T" sort="Laurie, Matthew T" uniqKey="Laurie M" first="Matthew T" last="Laurie">Matthew T. Laurie</name><name sortKey="Lebel, Paul" sort="Lebel, Paul" uniqKey="Lebel P" first="Paul" last="Lebel">Paul Lebel</name><name sortKey="Liu, Jamin" sort="Liu, Jamin" uniqKey="Liu J" first="Jamin" last="Liu">Jamin Liu</name><name sortKey="Marquez, Carina" sort="Marquez, Carina" uniqKey="Marquez C" first="Carina" last="Marquez">Carina Marquez</name><name sortKey="Martinez, Jackie" sort="Martinez, Jackie" uniqKey="Martinez J" first="Jackie" last="Martinez">Jackie Martinez</name><name sortKey="Miller, Steve" sort="Miller, Steve" uniqKey="Miller S" first="Steve" last="Miller">Steve Miller</name><name sortKey="Nakamura, Robert" sort="Nakamura, Robert" uniqKey="Nakamura R" first="Robert" last="Nakamura">Robert Nakamura</name><name sortKey="Pak, John" sort="Pak, John" uniqKey="Pak J" first="John" last="Pak">John Pak</name><name sortKey="Peng, James" sort="Peng, James" uniqKey="Peng J" first="James" last="Peng">James Peng</name><name sortKey="Petersen, Maya" sort="Petersen, Maya" uniqKey="Petersen M" first="Maya" last="Petersen">Maya Petersen</name><name sortKey="Rojas, Susana" sort="Rojas, Susana" uniqKey="Rojas S" first="Susana" last="Rojas">Susana Rojas</name><name sortKey="Rojas, Susy" sort="Rojas, Susy" uniqKey="Rojas S" first="Susy" last="Rojas">Susy Rojas</name><name sortKey="Rubio, Luis" sort="Rubio, Luis" uniqKey="Rubio L" first="Luis" last="Rubio">Luis Rubio</name><name sortKey="Sunshine, Sara" sort="Sunshine, Sara" uniqKey="Sunshine S" first="Sara" last="Sunshine">Sara Sunshine</name><name sortKey="Tulier Laiwa, Valerie" sort="Tulier Laiwa, Valerie" uniqKey="Tulier Laiwa V" first="Valerie" last="Tulier-Laiwa">Valerie Tulier-Laiwa</name><name sortKey="Wu, Wesley" sort="Wu, Wesley" uniqKey="Wu W" first="Wesley" last="Wu">Wesley Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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